NEWS & EVENTS

Listen to an overview of preclinical and clinical applications of our neuroanalytic platforms by our founder,

Dr. Monica Metea

RECENT CONFERENCES

Listen to an introduction to preclinical nerve conduction presented for our collaborators at Altasciences by our founder,

Dr. Monica Metea

Join us for networking

and workshops

We organize regular meetings to exchange ideas, learn about latest developments in neuroscience, and brainstorm applications.

  • Lucerum users meetings

  • Preclinical EEG-qEEG (pharma)

  • TMS guidance with qEEG (clinical)

  • Clinical qEEG discussion group

  • Neurofeedback focus

  • Peripheral nervous system e-phyz

  • 1:1 with our team members

SELECTED WORKS

PRESENTATIONS

  • Metea M., Crum L., Palmero Soler E., Predicting Neurotransmitter Contribution to Drug Effects on Brain Network Function Using EEG Tomography in Nonhuman Primates and Humans. Presentation at Society for Brain Mapping and Therapeutics 2024.

  • Anantharam P., Burenheide K., Hunziger A., Moore J., Beske P., Metea M., Saporito M. Intravenous Ganaxolone Attenuates Sarin Nerve Agent Induced Seizures. Presented at the American Epilepsy Society Annual Meeting, 2023.

  • Metea M., A drug development workbench platform for qEEG and multivariate data. Invited talk presented at the Safety Pharmacology Society Conference, 2023

  • Metea M., Palmero Soler E., Pierce E.B., Gould R.H..Characterization of drugs targeting the mu opioid receptor (MOR) Using Multivariate Quantitative Electroencephalography (qEEG) and Sleep/Wake Metrics. Poster presented at the Safety Pharmacology Society Conference, 2023

  • Metea M., Palmero Soler E., Holter K.M., Newman A.H, Gould R.H.. Characterization of Novel Selective DAT Inhibitors Using Multivariate qEEG and Sleep/Wake Metrics. Poster presented at the American College of Toxicology Conference, 2023

  • Rountree C., Metea M., Curley J.L., Terral M., Schmidt E., Moore M.J. Novel neurotoxicity screening platform to examine functional changes in rodent dorsal root ganglia and human iPSC-derived sensory neuron cultures. Poster presented at the Society of Toxicology Conference, 2023

  • Jahnke M.J., Metea M., Palmero Soler E., Preclinical electrophysiologic nerve conduction assessments of peripheral neuropathies (PN) secondary to administration of AAV-based gene therapies:  focus on early detection and severity ranking of sensory PN in primates. Poster presented at the Safety Pharmacology Society Conference, 2023

PUBLICATIONS

  • Buss N, Lanigan L, Zeller J, et al. Characterization of AAV-mediated dorsal root ganglionopathy. Mol Ther Methods Clin Dev. 2022;24:342-354. doi:10.1016/j.omtm.2022.01.013

  • Holzer P, Chang EJ, Rogers K, et al. Large-gap peripheral nerve repair using xenogeneic transplants in rhesus macaques. Xenotransplantation. 2023;30(2):e12792. doi:10.1111/xen.12792

  • Metea M, Palmero-Soler E, Crum L. Preclinical nerve conduction: Nerve battery options for primate studies. J Pharmacol Toxicol Methods. 2022;116:107187. doi:10.1016/j.vascn.2022.107187

  • Metea, M.R, Center, W., Messenheimer, J., EEG screening process using normative qEEG databases and topographical mapping, J Pharmacol Toxicol Methods 2020, Safety Pharmacology Society conference poster.

  • Metea M, Lyng GD, Mena JD. Nerve conduction assessments detect early changes in sensory and motor nerve function in a preclinical mouse model of chemotherapy-induced peripheral neuropathy (CIPN). Journal of Pharmacological and Toxicological Methods. 2019;99:106595. doi:10.1016/j.vascn.2019.05.079

  • Kearney KR, Jenkins CJ, Adkins NA, et al. Surface lead EEGs: Will it stick? Journal of Pharmacological and Toxicological Methods. 2019;99:106595. doi:10.1016/j.vascn.2019.05.071

  • Metea MR, Appleby C, Kearney K. Characterization of alfaxalone-induced seizures in dogs upon emergence from anesthesia. Journal of Pharmacological and Toxicological Methods. 2018;93:135. doi:10.1016/j.vascn.2018.01.451

  • Bradley J, Metea M, Strock CJ. Evaluating the pharmacology and neurotoxic predictability of neuroactive compounds using human induced pluripotent stem cell-derived glutamatergic neurons co-cultured with astrocytes using a microelectrode array platform. Journal of Pharmacological and Toxicological Methods. 2018;93:136-137. doi:10.1016/j.vascn.2018.01.456

  • Bradley JA, Luithardt HH, Metea MR, Strock CJ. In Vitro Screening for Seizure Liability Using Microelectrode Array Technology. Toxicological Sciences. 2018;163(1):240-253. doi:10.1093/toxsci/kfy029

  • Metea M, Litwak M, Arezzo J. Assessment of seizure risk in pre-clinical studies: Strengths and limitations of the electroencephalogram (EEG). Journal of Pharmacological and Toxicological Methods. 2015;75:135-142. doi:10.1016/j.vascn.2015.04.001

  • Metea M. Advantages and limitations of computerized methods for analysis of telemetry EEG data. Journal of Pharmacological and Toxicological Methods. 2015;75:162. doi:10.1016/j.vascn.2015.08.016

  • Gill R, Wakefield A, McPherson H, Piontek M, Best D, Gould K. Assessment of radio telemetry signal quality during blood sampling from the arterial or venous circulation in nonhuman primates. Journal of Pharmacological and Toxicological Methods. 2013;68(1):e17-e18. doi:10.1016/j.vascn.2013.01.070

  • Metea MR, Gleason TR, Atterson PR. Correlation between respiratory minute volumes and blood gas values in artificially-ventilated beagle dogs. Journal of Pharmacological and Toxicological Methods. 2012;66(2):196-197. doi:10.1016/j.vascn.2012.08.134

  • Metea MR, Gleason TR, Atterson PR. Cardiovascular and video-electroencephalogram (EEG) telemetry collection in freely moving beagle dogs—A qualification study. Journal of Pharmacological and Toxicological Methods. 2012;66(2):187. doi:10.1016/j.vascn.2012.08.101

  • Metea MR, Vidmar TJ, Shellhammer LJ, Atterson PR. Exploring filtering and correction factors in a standard dog cardiovascular model. Journal of Pharmacological and Toxicological Methods. 2011;64(1):e38. doi:10.1016/j.vascn.2011.03.135

  • Metea MR, Setzer JJ, Vidmar TJ, Shellhammer LJ, Atterson PR. Correlation between an external and an implanted telemetry system in conscious non-human primates. Journal of Pharmacological and Toxicological Methods. 2011;64(1):e43-e44. doi:10.1016/j.vascn.2011.03.152

  • Kearney K, Metea M, Gleason T, Edwards T, Atterson P. Evaluation of respiratory function in freely moving Beagle dogs using implanted impedance technology. J Pharmacol Toxicol Methods. 2010;62(2):119-126. doi:10.1016/j.vascn.2010.06.004

  • Metea MR, Newman EA. Signalling within the neurovascular unit in the mammalian retina. Exp Physiol. 2007;92(4):635-640. doi:10.1113/expphysiol.2006.036376

  • Metea MR, Kofuji P, Newman EA. Neurovascular coupling is not mediated by potassium siphoning from glial cells. J Neurosci. 2007;27(10):2468-2471. doi:10.1523/jneurosci.3204-06.2007

  • Metea MR, Newman EA. Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling. J Neurosci. 2006;26(11):2862-2870. doi:10.1523/JNEUROSCI.4048-05.2006

  • Metea MR, Newman EA. Calcium signaling in specialized glial cells. Glia. 2006;54(7):650-655. doi:10.1002/glia.20352