HANDS-ON

ELECTROPHYSIOLOGY EXPERTS

WHEN AND WHERE YOU NEED THEM

PCEC has developed and validated sensitive, rigorous, and reproducible preclinical electrophysiology data collection protocols for small and large animal models. Our scientists are expert electrophysiologists with decades of experience in conducting EEG and nerve conduction recordings.

With our state-of-the-art equipment and fast response, we travel to your facility and excel at adapting to the operational flow of any laboratory environment.

PRECLINICAL

EEG APPLICATIONS

  • Regulatory agencies like the FDA and EMA require comprehensive data to advance new drugs into clinical trials. Preclinical toxicology studies are essential for meeting these regulatory standards.

    For drugs targeted to the brain or posing a risk to the CNS, prestudy EEG analyses ensure that the animals placed on a study are free from any seizure risk, therefore increasing the confidence in drug-related events.

  • Toxicology studies are necessary for identifying toxic drug effects, determining safe dosages, complying with regulatory requirements, and assessing risks in drug development.

    However, the clinical observations common to preclinical toxicology studies are not sensitive enough to detect a true seizure risk. In such cases, EEG is added to a toxicology study to identify a seizure risk based on electrographic events.

    Our team has extensive experience with the science and the logistics of EEG add-ons and offers on-site collections when needed.

  • In addition to mitigating the risk of drug-induced seizures before Phase I clinical trials, EEG can be used to evaluate the pharmacodynamic effects of drugs on brain activity (pharmaco-EEG).

    This combined approach helps optimize dosing regimens and define the drug's impact on neural circuits.

EEG supports preclinical drug safety.

PRECLINICAL

NERVE CONDUCTION

Leading Experts in clinically translatable nerve conduction assays

Nerve conduction studies (NCS) and electromyography (EMG) are non-invasive, clinically translatable measures of peripheral nerve or neuromuscular dysfunction.

Preclinical NCS provide information comparable to evaluations of peripheral neuropathy in patients, e.g., assessing the type of fibers affected (motor, sensory or both) and the type of pathophysiology (axonal loss vs. demyelination).

Our validated assays allow sensitive detection of changes in nerve function, and are applicable to preclinical peripheral neuropathy de-risking, gene therapy, xenographic or nerve conduit validation, and muscle disease research.

We maintain normative databases unique in the preclinical space, supporting a rigorous interpretation of neuropathy severity. Our team has deep knowledge of anatomy in multiple species and nerve variants, and rigorous cross-training for inter-user reproducibility of data.

Preclinical Neuropathy Risk Assessment

COMPANION ANIMAL

ELECTROPHYSIOLOGY

We support veterinary clinics with diagnostic EEG and nerve conduction at select locations in the US.

Our team is currently developing applications of brain analytics for companion animals, for enhanced performance and wellbeing.

Let’s Network

Who can work with us?

  • Drug development teams

  • Clinical trial sites

  • Preclinical CROs

  • Defense / Countermeasures projects

  • Academic labs

  • Neuromodulation clinics

  • Neurologists, psychiatrists, psychologists, and clinicians using qEEG/t

  • Neurostimulation clinics

  • Neurotechnology developers

  • Consumers interested in brain biometrics