leaders in preclinical neuropathy derisking
ELECTROPHYSIOLOGY
PERIPHERAL NERVOUS SYSTEM
Preclinical Nerve Conduction
Nerve conduction studies evaluate nerve integrity, while EMG is the gold standard in assessing muscle dysfunction. Together, these tools aid in evaluating treatment efficacy, optimizing dosages, or ensuring drug safety. We are unsurpassed leaders in the development and execution of clinically translatable nerve conduction recording methods in rodents and large animals.
Drug Safety: Preclinical Neuropathy Derisking
We support your team in all preclinical neuropathy derisking decisions.
Our scientists have unparalleled field expertise and technical proficiency in electromyography (EMG) and nerve conduction studies across a wide spectrum of research applications.
Xenogenic Nerve Transplants and Conduits
Our scientists were instrumental to the success of many cutting-edge nerve regeneration studies, probing reinnervation and recovery using custom electrophysiology methodology.
Muscle Disease-Targeting Therapies
Nerve conduction studies and electromyography (EMG) play pivotal roles in researching mechanisms underlying muscle disease and in support of efficacy studies for targeted therapies.
PERIPHERAL NERVE RESEARCH
Increase preclinical safety profiles.
Avoid assay pitfalls.
Partner with our expert nerve conduction electrophysiologists.
Unparalleled peripheral nerve expertise, technical proficiency, and track record in EMG and nerve conduction studies across a wide spectrum of research applications.
GENE
THERAPY
Ensuring the safety profile of gene therapies
Nerve conduction studies are key clinically-translatable assays included in preclinical safety assessments of gene therapeutics. The expertise of seasoned electrophysiologists is indispensable in mitigating a risk of neuropathy.
Regulatory
In recent years, adenoassociated virus (AAV)-based gene therapies (GT), which have shown promise in the treatment of rare diseases, have become associated with adverse events related to the dorsal root ganglia (DRG) or peripheral nerve toxicities and has prompted renewed regulatory requirements.
We can help you frame the best approach in support of your drug safety program.
Sensory Nerves and DRG Focus
The effects of gene therapy on DRGs and sensory nerves is investigated with nerve conduction. Sensory nerve evaluations are difficult and require not only extensive electrophysiology training, but also experience with the specific species anatomy. Our technicians have thousands of hours of hands-on experience conducting sensory assays in rodents and large animals, thus delivering documented test sensititivity, unprecedented in the industry.
PCEC maintains the largest preclinical nerve conduction normative database for multiple species.
Assessments of neuropathy severity are meaningful only when benchmarked to a normal population. In addition to stringent and reproducible electrophysiology protocols, we offer a rigorously validated and clinically translatable approach to ranking the severity of neuropathy findings based on species-specific normative databases containing thousands of datapoints.
Nerve conduction parameters change with maturation in juvenile animals. We have mapped the growth patterns in rodents and large animals in support of sensitive assays for pediatric indications.
CROSS-SPECIES NORMATIVE DATABASE
We fit seamlessly into your operation with custom data collections and interpretative consultative services.
